US man recovers after change of pig heart | Health Issues

Doctors believe that genetic mutations can help a patient’s body accept the organ and that pig’s organs can help to reduce the risk of genital warts.

A man with a chronic heart disease responds positively three days after receiving a genetically modified pig’s heart during the first operation, his doctors said Monday.

The operation, performed by a team from the University of Maryland Medicine in the United States, is one of the first to demonstrate the potential for human-to-human transmission of a pig, a possible component with new genetic mutations.

If proven successful, scientists hope that pig’s limbs can help reduce the number of donor organs.

“This was a very successful operation and it brought us closer to the problem of amputation. There are not enough hearts of people to donate to complete the long list of potential recipients,” said Dr Bartley Griffith, who put a pig’s heart in a patient.

“We are acting responsibly, but we are also hopeful that the first surgery in the world will provide the necessary new path for patients in the future,” added Griffith.

For David Bennett, 57, of Maryland, concentration was his last resort.

“It was dying or doing this. I want to live. I know I’m shooting in the dark, but it’s my final decision,” Bennett said a day before surgery, according to a university report.

David Bennett, 57, looks after surgeon Bartley P Griffith before receiving a genetically modified pork transplant at the University of Maryland Medical Center in Baltimore [University of Maryland School of Medicine via Reuters]

To advance the experimental work, the university received an emergency permit from the U.S. Food and Drug Administration on New Year’s Eve through its charitable application program.

“The FDA used our data and data on the experimental pig to approve the implantation of a cardiovascular patient who had no other means,” said Dr Muhammad Mohiuddin, who is leading the university’s program on xenotransplantation – implantation of animal organs in humans. .

An estimated 110,000 Americans are waiting for a transplant, and more than 6,000 patients die each year before receiving it, according to

The genetically modified Bennett pig’s heart was donated by Revivicor, a Virginia pharmaceutical company. On the day of the operation, the designated team removed the pig’s heart and placed it in a special device to preserve its function until the operation.

Pigs have long been involved in artificial insemination because their organs are so similar to those of humans.

Other parts of the pig that are being researched in humans include the kidneys, liver and lungs.

Previous experiments on the transfer of pigs to humans have been unsuccessful because of genetic mutations that result in genetic resistance or viruses that cause disease.

Scientists have tackled this problem by changing genes that can be dangerous.

In a Bennett-implanted heart, three genes that had previously been linked to organ transplantation were “released” into the donor pig, and six genes involved in immune acceptance were incorporated into the pig genome.

Researchers also removed the pig gene to prevent the rapid growth of pig heart muscle.

The project was funded by a $ 15.7 million Revivicor pig heart study in monkey studies.

In addition to genetic mutations in pigs’ heart, Bennett received experimental drug resistance.

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